Lauriaselle Afanador Haley Yarosh Jing Wang Syed F. Ali Jesus A. Angulo
Published in
Journal of Drug and Alcohol Research
Several laboratories have shown that methamphetamine (METH) neurotoxicity is associated with increases of nitric oxide (NO) production in striatal tissue and blockade of NO production protects from METH. Because substance P modulates NO production, we tested the hypothesis that intrinsic striatal neuropeptides such as somatostatin and neuropeptide ...
Tran Le Ming Tong VanAnh Nguyen Suzanne de la Monte
Published in
Journal of Drug and Alcohol Research
Cerebellar abnormalities in fetal alcohol spectrum disorder (FASD) have been linked to brain insulin resistance and oxidative stress. Peroxisome proliferator-activated receptor (PPAR) agonists, which have insulin sensitizer and antioxidant effects, could potentially be used to treat neurodevelopmental abnormalities in FASD. Slice cultures generated...
Fatima Kaneez Kejing Zhu Liming Tie Nurul Bahriah Haji Osman
Published in
Journal of Drug and Alcohol Research
Internet addiction disorder (IAD) has been proposed to describe uncontrollable, damaging use of Internet technology leading to some changes in the autonomic nervous system. IAD can be defined as an impulse-control disorder that does not involve an intoxicant. Diagnostic and Statistical Manual of Mental Disorders (DSM-V) does not recognize it as a d...
Susan Schenk Joyce Colussi-Mas Jennifer Do Judith Bird
Published in
Journal of Drug and Alcohol Research
The present study provides a profile of acquisition and maintenance of self-administration of +/-3,4-methylenedioxymethamphetamine (MDMA) obtained from a large cohort of rats tested during a 2 year period. Of the 128 rats, 49% self-administered 1.0 mg/kg/infusion MDMA to an initial criterion within a 25 day cutoff period. The number of test session...
Nagisa Sugaya Toru Kobayashi Kazutaka Ikeda
Published in
Journal of Drug and Alcohol Research
G-protein-activated inwardly rectifying potassium (GIRK) channels are widely expressed in the central nervous system, including brain regions related to reward, and play an important role in mediating the signal transduction pathways of various addictive substances. Studies of GIRK knockout mice have suggested the involvement of GIRK channels in th...
Fang Liu Xuan Zhang Tucker Patterson Shuliang Liu Syed F. Ali Merle Paule William Slikker Jr. Cheng Wang
Published in
Journal of Drug and Alcohol Research
Anesthetics have been used for years in pediatric patients without clinical evidence of adverse central nervous system (CNS) sequelae. In the current study, postnatal day (PND) 5–6 rhesus monkeys were exposed to nitrous oxide (N 2 O; 70%) alone, isoflurane (ISO; 1.0%) alone, or N 2 O plus ISO for 8 h. Six hours after completion of anesthetic admini...
Cheng Wang Fang Liu Tucker Patterson Merle Paule William Slikker
Published in
Journal of Drug and Alcohol Research
Introduction. Because of obvious concerns, it is not possible to thoroughly explore the adverse effects of anesthetics in children. However, the availability of neural stem cell derived models has provided an invaluable tool to examine the etiology of neurotoxicity associated with developmental exposure to general anesthetics. Stem cells and neurot...
Han Kong ming xu
Published in
Journal of Drug and Alcohol Research
Memories of learned associations between the rewarding properties of drugs and environmental cues contribute significantly to craving and relapse in humans. We have investigated how dopamine (DA) D1 and D3 receptors modulate the acquisition and extinction of cocaine-induced reward learning and associated changes in cellular signaling in reward circ...
Sulie L. Chang Sraboni Sarkar Michael Vigorito Xin Mao
Published in
Journal of Drug and Alcohol Research
Morphine, used clinically for pain management for its potent analgesic effects, has a high abuse potential. In this study, we utilized the conditioned place preference (CPP) paradigm and tail-flick latency to examine the effects of the endotoxin lipopolysaccharide (LPS) on sensitivity to morphine. Rats were pretreated with either LPS (250 μg/kg) or...
Alexandra Ewenczyk Ashley Conoway Jason Ziplow Tran Le Quynh-Giao Nguyen William Cy Chen Ming Tong Valerie Zabala Suzanne de la Monte
Published in
Journal of Drug and Alcohol Research
Background. Neurodevelopmental abnormalities in fetal alcohol spectrum disorder (FASD) are associated with impaired insulin and IGF signaling, which is needed for neuronal growth, survival, and plasticity. We characterized effects of the L-165,041 PPAR-δ agonist insulin sensitizer on cerebellar structure and function in relation to insulin/IGF and ...
