γ-hydroxybutyric acid (GHB) causes retrograde amnesia in juveniles and young adults. Earlier, we have reported that in adolescent rat, GHB impairs the hidden platform task performance in the Morris water maze. In the present study, a classical fear conditioning paradigm was used to examine the effects of GHB on the acquisition of con-textual condit...
In the immature brain, ethanol impairs insulin, insulin-like growth factor (IGF) and other trophic factor signaling, increases cellular stress, and impairs neuronal and glial functions. However, given the phenotypic heterogeneity of fetal alcohol spectrum disorder (FASD), which is not always ethanol dose-dependent, we hypothesized that cofactors mo...
The continued abuse of inhaled organic solvents, especially among women of childbearing age, raises the risk of long-term behav-ioral effects of maternal toluene abuse. In this study, the effects of short-term exposures to high toluene concentrations (i.e., " binges ") were tested in independent groups of adolescent rats with different toluene trea...
Nasal septal abscess is an uncommon condition. This paper describes a case of nontraumatic, nasal septal abscess in an immune-competent child with no evidence of sinusitis or other localized infections. A 7-month-old infant with a 2-day history of nasal obstruction, fever, and a swollen, erythematous nose was admitted to our hospital. Physical exam...
Resident attrition is a significant issue facing graduate surgical education, with broad implications for trainees, their families, educators, and society at large. Resident attrition is costly and often may represent a poor initial selection process, inadequate training in medical school, or insufficient feedback and mentoring while the resident i...
We have recently documented that cocaine-induced MEF2C expression in rat brain is mediated by the activation of the salt-inducible kinase SIK1, which is itself regulated by phosphorylation mechanisms. We report here that acute or chronic treatment of rats with cocaine increased the expression of the catalytic subunit of protein phosphatase PP2A in ...
The Lewis (LEW) and Fischer 344 (F344) rat strains are widely used as models of genetic vulnerability to drug addiction, particularly since these two strains show different patterns of drug self-administration. We previously performed an unbiased and genome-wide microarray analysis to define the differences in gene expression in the nucleus accumbe...
Objective. We report a complication of endoscopic Zenker's diverticulum repair after postoperative continuous positive airway pressure (CPAP) use. Study design. Case report and literature review. Results. Patient presented for Zenker's diverticulum repair. He was treated endoscopically with gastrointestinal anastomosis stapler and carbon dioxide la...
Sinonasal melanoma is a rare disease with limited data regarding its optimal treatment. It is an aggressive disease with up to 60% of patients developing local recurrence or distant metastases in the first 24 months after treatment. We report a case of sinonasal melanoma involving the skull base which was treated by endoscopic anterior craniofacial...
We report the case of a 48-year-old female who presented to our clinic 8 years after silicone implant forehead augmentation with complaints of brow swelling, tenderness, and periorbital edema. Imaging revealed non-rim enhancing fluid collection and underlying bony ridges. Ensuing medical management included antibiotics which lead to resolution of t...
