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Endotoxin Enhancement of Morphine-Induced Conditioned Place Preference

Sulie L. Chang Sraboni Sarkar Michael Vigorito Xin Mao

Published in Journal of Drug and Alcohol Research

Morphine, used clinically for pain management for its potent analgesic effects, has a high abuse potential. In this study, we utilized the conditioned place preference (CPP) paradigm and tail-flick latency to examine the effects of the endotoxin lipopolysaccharide (LPS) on sensitivity to morphine. Rats were pretreated with either LPS (250 μg/kg) or...

The Effects of Proximal and Distal Social Stimulation on Ethanol Intake in Male and Female CD-1 Mice

Arthur Tomie Allison Gayle Samuel Alam Merchant Lei Yu

Published in Journal of Drug and Alcohol Research

Background. Proximal and distal social stimulation increase ethanol drinking in humans. Purpose. Our study evaluated the effects of proximal and distal social stimulation on home-cage ethanol drinking in mice. Study design. Proximal cagemate drinking (PCD) procedures use a clear plastic barrier to separate the drinker mouse from the proximal cagema...

Protective Effects of Caffeic Acid on Quinolinic Acid-Induced Behavioral and Oxidative Alterations in Rats

Ana Laura Colín-González Sayde Sánchez-Hernández Maria Eduarda de Lima Syed F. Ali Anahí Chavarría Juana Villeda Abel Santamaría

Published in Journal of Drug and Alcohol Research

Study design. The protective effects of the natural antiox-idant caffeic acid (CA) on behavioral tasks and lipid peroxidation were tested in an excitotoxic model produced by unilateral intrastriatal injection of quinolinic acid (QUIN), and in striatal slices incubated in the presence of the same toxin. CA (20 mg/kg) was administered intraperitoneal...

Ehlers-Danlos Syndrome Presenting as Airway Obstruction and Hoarseness

Jessica Seebald Joseph Muscarella

Published in Journal of Case Reports in Medicine

Ehlers-Danlos syndrome is an autosomal dominant genetic defect in connective tissue synthesis and structure. The genetic disorder is classified into six major types based on clinical signs and symptoms as well as genetic testing. We describe the case of a 42-year-old female who presents with dyspnea and hoarseness. After an anterior glottic web was...

Study of Coronary Risk Factors in Rural Malaysia Population

M. Aye J. S. F. Cabot M. Sazali

Published in International Journal of Medical Biology

Coronary artery disease (CAD) is the global leading cause of death for both men and women. Risk factors for CAD have been studied extensively and subsequently preventive and treatment measures have been prioritized globally. Nevertheless, the prevalence and mortality rate of CAD remains high. We attempted to identify the most common of the well-kno...

Anesthetic Drug-Induced Neurotoxicity and Compromised Neural Stem Cell Proliferation

Cheng Wang Fang Liu Tucker Patterson Merle Paule William Slikker

Published in Journal of Drug and Alcohol Research

Introduction. Because of obvious concerns, it is not possible to thoroughly explore the adverse effects of anesthetics in children. However, the availability of neural stem cell derived models has provided an invaluable tool to examine the etiology of neurotoxicity associated with developmental exposure to general anesthetics. Stem cells and neurot...

Beta-Blockers, a Spanner in the Works for Acute Management of Migraine?

Susannah Leaf

Published in Journal of Case Reports in Medicine

Many patients suffer with migraine and do not feel their therapeutic needs are met, particularly in acute treatment. Beta-blockers are inexpensive, well-tolerated medications licensed for prophylaxis of migraine but not for acute treatment of episodic migraine (EM). However, this is based on trials that are possibly too narrow. A known association ...

Effect of Short-Term Temperature Change on Cercarial Release by Rhipidocotyle fennica (Trematoda, Bucephalidae) from the...

Jocelyn Choo Jouni Taskinen

Published in Ecological Parasitology and Immunology

Cercarial release from the first intermediate host is an important stage in the transmission of trematode parasites. Besides long-term (seasonal) temperature fluctuations, short-term temperature changes can also influence cercarial emergence. We tested the response of the bucephalid trematode, Rhipidocotyle fennica (R. fennica), acclimatized to 17 ...

Alcoholic Steatosis in Different Strains of Rat: A Comparative Study

Kamlesh K. Bhopale Shakuntala Kondraganti Harshica Fernando Paul Boor Bhupendra Kaphalia G. A. Shakeel Ansari

Published in Journal of Drug and Alcohol Research

Background. Different strains of rats have been used to study alcoholic liver disease (ALD) while the reason for selecting a particular rat strain was not apparent. Purpose. The aim of our study was to compare outbred (Wistar) and inbred (Fischer) strains to evaluate pathological, biochemical changes, and gene expression differences associated with...

Klebsiella pneumoniae Cervical Necrotizing Fasciitis Secondary to Bacterial Parotitis: A Case Report

Chien-wei Pan Chung-ching Hung

Published in Journal of Case Reports in Medicine

Cervical necrotizing fasciitis is a fulminant infection that spreads along the fascial planes, causing subcutaneous tissue death characterized by rapid progression and systemic toxicity. Dental infection is the most common nidus of cervical necrotizing fasciitis. Strep-tococcus and Staphylococcus species are found to be the most commonly isolated o...

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