Background. Proximal and distal social stimulation increase ethanol drinking in humans. Purpose. Our study evaluated the effects of proximal and distal social stimulation on home-cage ethanol drinking in mice. Study design. Proximal cagemate drinking (PCD) procedures use a clear plastic barrier to separate the drinker mouse from the proximal cagema...
Morphine, used clinically for pain management for its potent analgesic effects, has a high abuse potential. In this study, we utilized the conditioned place preference (CPP) paradigm and tail-flick latency to examine the effects of the endotoxin lipopolysaccharide (LPS) on sensitivity to morphine. Rats were pretreated with either LPS (250 μg/kg) or...
Study design. The protective effects of the natural antiox-idant caffeic acid (CA) on behavioral tasks and lipid peroxidation were tested in an excitotoxic model produced by unilateral intrastriatal injection of quinolinic acid (QUIN), and in striatal slices incubated in the presence of the same toxin. CA (20 mg/kg) was administered intraperitoneal...
Background. Nicotine is one of the most frequently used drugs of abuse. It has long been speculated that in addition to nicotine , tobacco contains other compounds that reinforce addiction. Two promising candidates are the tobacco smoke constituents, harmane and norharmane. Purpose. Our study evaluated the effects of exposure to harmane and norharm...
How genetically simple pathogens like HIV overwhelm complex immune systems is not fully understood. One unexplored possibility is that epistatic interactions across genetically complementary quasispecies (i.e., group-level social heterosis) allow pathogens to escape immune suppression. We tested this hypothesis by simulating an " HIV-like " pathoge...
Les auteurs rapportent un cas rare de tumeur à cellules granuleuses du clitoris chez une patiente âgée de 38 ans et font une brève revue de la littérature.
In this descriptive retrospective study, we reviewed 300 cases of Burkitt's lymphoma (BL) diagnosed within 10 years from January 1, 2000 to December 31, 2010. The study took place in the pathology laboratories of the Central Hospital and the General Hospital in Yaoundé, Cameroon. The aim was to review the anatomo-clinical and epidemiological aspect...
Objective. Non-neoplastic and neoplastic mucosal lesions from orophayngolaryngeal region constitute a major health problem in developing countries. Carcinoma of this region is the commonest neoplasm in male in our country. The study was aimed at testing for the accuracy of cytological diagnosis as well as morphometry analysis and compared with hist...
Introduction. Plusieurs scores ont été proposés à l'histopa-thologie du matériel de biopsie hépatique dans le cadre de la prise en charge des hépatites virales chroniques parmi lesquels le score de Knodell et le score Métavir. L'objectif de notre travail était de com-parer la reproductibilité des scores Métavir et de Knodell pour déter-miner lequel...
Dear Colleagues, As you probably know, significant concern has developed over the irreproducibility of published results, and the NIH has expressed serious concern over this problem [1, 4]. There is no real worry that this is due to scientific misconduct. Rather, it is believed to be due to poor training of investigators in experimental design, lac...
